Preparing for Chemical Terrorism: Stability of Injectable Atropine Sulfate
نویسندگان
چکیده
منابع مشابه
IMPROVED CHROMATOGRAPHIC METHOD FOR DETERMINATION OF SODIUM DICLOFENAC IN INJECTABLE SOLUTION AND PREDICTION OF CHEMICAL STABILITY
Two modified methods for assaying sodium diclofenac were developed by GC and HPLC. Diclofenac was converted into methyl ester derivative by methyl iodide in acetone. The ester was extract and subjected to GLC with flame ionization detector. %5 SE-30/chrom W-HP (80-100 mesh) was used as a column in GC. For reversed phase HPLC, the mobile phase was methanol and water (55-45). The separation was p...
متن کاملDevelopment of a Combined Solution Formulation of Atropine Sulfate and Obidoxime Chloride for Autoinjector and Evaluation of Its Stability
Atropine (AT) and oximes, alone or in combination, have been proven greatly valuable therapeutics in the treatment of organophosphates intoxications. An injectable mixture of AT and obidoxime (OB) was formulated for administration by automatic self-injector. The aqueous single dose solution contained 275 mg obidoxime chloride and 2.5 mg atropine sulfate per 1 ml (220 mg and 2 mg per 0.8 effecti...
متن کاملDevelopment of a Combined Solution Formulation of Atropine Sulfate and Obidoxime Chloride for Autoinjector and Evaluation of Its Stability
Atropine (AT) and oximes, alone or in combination, have been proven greatly valuable therapeutics in the treatment of organophosphates intoxications. An injectable mixture of AT and obidoxime (OB) was formulated for administration by automatic self-injector. The aqueous single dose solution contained 275 mg obidoxime chloride and 2.5 mg atropine sulfate per 1 ml (220 mg and 2 mg per 0.8 effecti...
متن کاملimproved chromatographic method for determination of sodium diclofenac in injectable solution and prediction of chemical stability
two modified methods for assaying sodium diclofenac were developed by gc and hplc. diclofenac was converted into methyl ester derivative by methyl iodide in acetone. the ester was extract and subjected to glc with flame ionization detector. %5 se-30/chrom w-hp (80-100 mesh) was used as a column in gc. for reversed phase hplc, the mobile phase was methanol and water (55-45). the separation was p...
متن کاملChemical terrorism for the intensivist.
The use of chemical agents for terrorist attacks or military warfare is a major concern at the present time. Chemical agents can cause significant morbidity, are relatively inexpensive, and are easy to store and use. Weaponization of chemical agents is only limited by the physicochemical properties of some agents. Recent incidents involving toxic industrial chemicals and chemical terrorist atta...
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ژورنال
عنوان ژورنال: Academic Emergency Medicine
سال: 2004
ISSN: 1069-6563
DOI: 10.1197/j.aem.2003.06.014